Data/hora: 08/06/2024 08:53:53

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | The relationship between anxiety and depression in animal models: a study using the forced swimming test and elevated plus-maze
Autores: | Andreatini,R.; Bacellar,L.F.S.
Data: | 1999-09-01
Ano: | 1999
Palavras-chave: | Anxiety; Depression; Comorbidity; Animal models.
Resumo: | The present study evaluated the correlation between the behavior of mice in the forced swimming test (FST) and in the elevated plus-maze (PM). The effect of the order of the experiments, i.e., the influence of the first test (FST or PM) on mouse behavior in the second test (PM or FST, respectively) was compared to handled animals (HAND). The execution of FST one week before the plus-maze (FST-PM, N = 10), in comparison to mice that were only handled (HAND-PM, N = 10) in week 1, decreased % open entries (HAND-PM: 33.6 ± 2.9; FST-PM: 20.0 ± 3.9; mean ± SEM; P&amp;lt;0.02) and % open time (HAND-PM: 18.9 ± 3.3; FST-PM: 9.0 ± 1.9; P&amp;lt;0.03), suggesting an anxiogenic effect. No significant effect was seen in the number of closed arm entries (FST-PM: 9.5 (7.0-11.0); HAND-PM: 10.0 (4.0-14.5), median (interquartile range); U = 46.5; P&amp;gt;0.10). A prior test in the plus-maze (PM-FST) did not change % immobility time in the FST when compared to the HAND-FST group (HAND-FST: 57.7 ± 3.9; PM-FST: 65.7 ± 3.2; mean ± SEM; P&amp;gt;0.10). Since these data suggest that there is an order effect, the correlation was evaluated separately with each test sequence: FST-PM (N = 20) and PM-FST (N = 18). There was no significant correlation between % immobility time in the FST and plus-maze indexes (% time and entries in open arms) in any test sequence (r: -0.07 to 0.18). These data suggest that mouse behavior in the elevated plus-maze is not related to behavior in the forced swimming test and that a forced swimming test before the plus-maze has an anxiogenic effect even after a one-week interval.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000900011
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1999000900011
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.32 n.9 1999
Fonte: | info:eu-repo/semantics/openAccess