Data/hora: 04/06/2024 18:36:39

Provedor de dados: | 56
País: | Brazil
Título: | Metabolic fate of glutamine in lymphocytes, macrophages and neutrophils
Autores: | Curi,R.; Newsholme,P.; Pithon-Curi,T.C.; Pires-de-Melo,M.; Garcia,C.; Homem-de-Bittencourt Jr.,P.I.; Guimarães,A.R.P.
Data: | 1999-01-01
Ano: | 1999
Palavras-chave: | Glutamine; Lymphocytes; Macrophages; Neutrophils; Metabolic fate.
Resumo: | Eric Newsholme's laboratory was the first to show glutamine utilization by lymphocytes and macrophages. Recently, we have found that neutrophils also utilize glutamine. This amino acid has been shown to play a role in lymphocyte proliferation, cytokine production by lymphocytes and macrophages and phagocytosis and superoxide production by macrophages and neutrophils. Knowledge of the metabolic fate of glutamine in these cells is important for the understanding of the role and function of this amino acid in the maintenance of the proliferative, phagocytic and secretory capacities of these cells. Glutamine and glucose are poorly oxidized by these cells and might produce important precursors for DNA, RNA, protein and lipid synthesis. The high rate of glutamine utilization and its importance in such cells have raised the question as to the source of this glutamine, which, according to current evidence, appears to be muscle.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000100002
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1999000100002
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.32 n.1 1999
Fonte: | info:eu-repo/semantics/openAccess