Data/hora: 04/06/2024 02:16:12

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Effect of L-carnitine on exercise performance in patients with mitochondrial myopathy	
Autores: 	Gimenes,A.C.; Bravo,D.M.; Nápolis,L.M.; Mello,M.T.; Oliveira,A.S.B.; Neder,J.A.; Nery,L.E.	
Data: 	2015-04-01	
Ano: 	2015	
Palavras-chave: 	Exercise tolerance; Muscle strength; Mitochondrial myopathy; L-carnitine supplementation.	
Resumo: 	Exercise intolerance due to impaired oxidative metabolism is a prominent symptom in patients with mitochondrial myopathy (MM), but it is still uncertain whether L-carnitine supplementation is beneficial for patients with MM. The aim of our study was to investigate the effects of L-carnitine on exercise performance in MM. Twelve MM subjects (mean age±SD=35.4±10.8 years) with chronic progressive external ophthalmoplegia (CPEO) were first compared to 10 healthy controls (mean age±SD=29±7.8 years) before they were randomly assigned to receive L-carnitine supplementation (3 g/daily) or placebo in a double-blind crossover design. Clinical status, body composition, respiratory function tests, peripheral muscle strength (isokinetic and isometric torque) and cardiopulmonary exercise tests (incremental to peak exercise and at 70% of maximal), constant work rate (CWR) exercise test, to the limit of tolerance [Tlim]) were assessed after 2 months of L-carnitine/placebo administration. Patients with MM presented with lower mean height, total body weight, fat-free mass, and peripheral muscle strength compared to controls in the pre-test evaluation. After L-carnitine supplementation, the patients with MM significantly improved their Tlim (14±1.9 vs 11±1.4 min) and oxygen consumption (      V ˙ O 2) at CWR exercise, both at isotime (1151±115 vs 1049±104 mL/min) and at Tlim (1223±114 vs 1060±108 mL/min). These results indicate that L-carnitine supplementation may improve aerobic capacity and exercise tolerance during high-intensity CWRs in MM patients with CPEO.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400354	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/1414-431x20143467	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.48 n.4 2015	
Fonte: 	info:eu-repo/semantics/openAccess