Data/hora: 08/06/2024 01:13:43

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Prostanoids modulate inflammation and alloimmune responses during graft rejection
Autores: | Rocha,P.N.; Carvalho,E.M.
Data: | 2005-12-01
Ano: | 2005
Palavras-chave: | Thromboxane; Prostaglandins; Transplantation; Inflammation; Rejection; Corticosteroids.
Resumo: | Acute rejection of a transplanted organ is characterized by intense inflammation within the graft. Yet, for many years transplant researchers have overlooked the role of classic mediators of inflammation such as prostaglandins and thromboxane (prostanoids) in alloimmune responses. It has been demonstrated that local production of prostanoids within the allograft is increased during an episode of acute rejection and that these molecules are able to interfere with graft function by modulating vascular tone, capillary permeability, and platelet aggregation. Experimental data also suggest that prostanoids may participate in alloimmune responses by directly modulating T lymphocyte and antigen-presenting cell function. In the present paper, we provide a brief overview of the alloimmune response, of prostanoid biology, and discuss the available evidence for the role of prostaglandin E2 and thromboxane A2 in graft rejection.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001200004
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2005001200004
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.38 n.12 2005
Fonte: | info:eu-repo/semantics/openAccess