Data/hora: 01/06/2024 18:19:29

Provedor de dados: | 56
País: | Brazil
Título: | Participation of kinins in the inhibitory action of captopril on acute hypertension induced by L-NAME in anesthetized rats
Autores: | Soares de Moura,R.; Cardoso,M.
Data: | 1997-10-01
Ano: | 1997
Palavras-chave: | L-NAME.
Resumo: | The aim of the present study was to investigate the role of bradykinin in the inhibitory action of captopril in hypertension induced by L-NAME in anesthetized rats. Male Wistar rats (260-320 g) were anesthetized with chloralose and arterial blood pressure was recorded with a polygraph pressure transducer. The hypertensive effect of L-NAME was studied in rats pretreated with saline, captopril or HOE 140 plus captopril. The effect of captopril was also studied during the sustained pressor effect of L-NAME. The acute pressor effect of L-NAME (10 mg/kg, iv) was significantly reduced by iv pretreatment with 2 mg/kg captopril (&lt;!-- $MVD$:face("Symbol") --&gt;&lt;FONT FACE="Symbol"&gt;D&lt;/font&gt; increase of 49 ± 4.9 mmHg reduced to 20 ± 5.4 mmHg, P = 0.01). The pressor effect of L-NAME (&lt;!-- $MVD$:face("Symbol") --&gt;&lt;FONT FACE="Symbol"&gt;D&lt;/font&gt; increase of 38 ± 4.8 mmHg) observed in rats pretreated with captopril and HOE 140 (0.1 mg/kg, iv) was not significantly different from that induced by L-NAME in rats pretreated with saline (P = 0.09). During the sustained pressor effect induced by L-NAME (&lt;!-- $MVD$:face("Symbol") --&gt;&lt;FONT FACE="Symbol"&gt;D&lt;/font&gt; increase of 49 ± 4.9 mmHg) captopril induced a significant (P&amp;lt;0.05) reduction in arterial blood pressure (&lt;!-- $MVD$:face("Symbol") --&gt;&lt;FONT FACE="Symbol"&gt;D&lt;/font&gt; decrease of 22 ± 3.0 mmHg). The present results demonstrate that the acute pressor effect of L-NAME is reduced by captopril and this inhibitory effect may be partly dependent on the potentiation of the vasodilator actions of bradykinin
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000013
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1997001000013
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.30 n.10 1997
Fonte: | info:eu-repo/semantics/openAccess