Data/hora: 29/05/2024 00:55:42

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Role of Th1 and Th2 cells in autoimmune demyelinating disease
Autores: | Nagelkerken,L.
Data: | 1998-01-01
Ano: | 1998
Palavras-chave: | Multiple sclerosis; Experimental allergic encephalomyelitis; Cytokines; Glucocorticoids; Th1 cells; Antigen-presenting cells.
Resumo: | Evidence is accumulating that Th1 cells play an important role in the development of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), whereas Th2 cells contribute to recovery from disease. A major determinant in the development of Th1 and Th2 cells is the type of antigen-presenting cell (APC) involved and its functional characteristics, e.g., the production of interleukin-12. Therefore, modulation of APC might interfere with the development of Th1 type responses and as such be beneficial for MS and EAE. The potential of cytokines, in particular interleukin-10, and glucocorticoids to exert a selective effect on APC, and as a consequence to affect the Th1-Th2 balance in EAE, is discussed
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100007
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1998000100007
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.31 n.1 1998
Fonte: | info:eu-repo/semantics/openAccess