Data/hora: 11/06/2024 02:44:26

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders
Autores: | Li,Jin-bo; Zhang,Rui; Han,Xiao; Piao,Chun-li.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | Diabetes; Ginsenoside Rg1; Insulin resistance; Body weight; Obesity.
Resumo: | Obesity and its consequent type 2 diabetes are significant threats to global health. Emerging evidence indicates that ginsenosides from ginseng (Panax ginseng) have anti-diabetic activity. We hypothesized that ginsenosides Rg1 could suppress dietary-induced obesity and improve obesity-related glucose metabolic disorders. Our results showed that ginsenoside Rg1 attenuated dietary-induced body weight gain and fat accumulation in white adipocyte tissue of mice fed a high-fat diet. Furthermore, we found that ginsenosides Rg1 not only decreased fasting glucose concentration and the 2-h postprandial glucose concentration, but also improved insulin resistance and glucose intolerance in those mice. Ginsenoside Rg1 also activated the AMPK pathway in vitro and in vivo and increased plasma membrane translocation of GLUT4 in C2C12 skeletal muscle cells. In conclusion, our observations suggested that ginsenoside Rg1 inhibited dietary-induced obesity and improved obesity-related insulin resistance and glucose intolerance by activation of the AMPK pathway.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000400610
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20177139
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.51 n.4 2018
Fonte: | info:eu-repo/semantics/openAccess