Data/hora: 04/06/2024 05:28:08

Provedor de dados: | 56
País: | Brazil
Título: | Decreased gastric emptying and gastrointestinal and intestinal transits of liquid after complete spinal cord transection in awake rats
Autores: | Gondim,F. de-A.A.; da-Graça,J.R.V.; de-Oliveira,G.R.; Rêgo,M.C.V.; Gondim,R.B.M.; Rola,F.H.
Data: | 1998-12-01
Ano: | 1998
Palavras-chave: | Gastric emptying; Gastrointestinal motility; Gastrointestinal transit; Intestinal transit; Rats; Spinal cord transection.
Resumo: | We studied the effect of complete spinal cord transection (SCT) on gastric emptying (GE) and on gastrointestinal (GI) and intestinal transits of liquid in awake rats using the phenol red method. Male Wistar rats (N = 65) weighing 180-200 g were fasted for 24 h and complete SCT was performed between C7 and T1 vertebrae after a careful midline dorsal incision. GE and GI and intestinal transits were measured 15 min, 6 h or 24 h after recovery from anesthesia. A test meal (0.5 mg/ml phenol red in 5% glucose solution) was administered intragastrically (1.5 ml) and the animals were sacrificed by an iv thiopental overdose 10 min later to evaluate GE and GI transit. For intestinal transit measurements, 1 ml of the test meal was administered into the proximal duodenum through a cannula inserted into a gastric fistula. GE was inhibited (P&amp;lt;0.05) by 34.3, 23.4 and 22.7%, respectively, at 15 min, 6 h and 24 h after SCT. GI transit was inhibited (P&amp;lt;0.05) by 42.5, 19.8 and 18.4%, respectively, at 15 min, 6 h and 24 h after SCT. Intestinal transit was also inhibited (P&amp;lt;0.05) by 48.8, 47.2 and 40.1%, respectively, at 15 min, 6 h and 24 h after SCT. Mean arterial pressure was significantly decreased (P&amp;lt;0.05) by 48.5, 46.8 and 41.5%, respectively, at 15 min, 6 h and 24 h after SCT. In summary, our report describes a decreased GE and GI and intestinal transits in awake rats within the first 24 h after high SCT.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001200015
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1998001200015
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.31 n.12 1998
Fonte: | info:eu-repo/semantics/openAccess