Data/hora: 16/06/2024 09:35:42

Provedor de dados: | 56
País: | Brazil
Título: | Breathing disorders in congestive heart failure: gender, etiology and mortality
Autores: | Silva,R.S.; Figueiredo,A.C.; Mady,C.; Lorenzi-Filho,G.
Data: | 2008-03-01
Ano: | 2008
Palavras-chave: | Sleep apnea; Cheyne-Stokes respiration; Congestive heart failure; Gender; Chagas' disease.
Resumo: | We investigated the relationship between sleep-disordered breathing (SDB) and Cheyne-Stokes respiration (CSR) while awake as well as mortality. Eighty-nine consecutive outpatients (29 females) with congestive heart failure (CHF; left ventricular ejection fraction, LVEF &lt;45%) were prospectively evaluated. The presence of SDB and of CSR while awake before sleep onset was investigated by polysomnography. SDB prevalence was 81 and 56%, using apnea-hypopnea index cutoffs &gt;5 and &gt;15, respectively. CHF etiologies were similar according to the prevalence of SDB and sleep pattern. Males and females were similar in age, body mass index, and LVEF. Males presented more SDB (P = 0.01), higher apnea-hypopnea index (P = 0.04), more light sleep (stages 1 and 2; P &lt; 0.05), and less deep sleep (P &lt; 0.001) than females. During follow-up (25 ± 10 months), 27% of the population died. Non-survivors had lower LVEF (P = 0.01), worse New York Heart Association (NYHA) functional classification (P = 0.03), and higher CSR while awake (P &lt; 0.001) than survivors. As determined by Cox proportional model, NYHA class IV (RR = 3.95, 95%CI = 1.37-11.38, P = 0.011) and CSR while awake with a marginal significance (RR = 2.96, 95%CI = 0.94-9.33, P = 0.064) were associated with mortality. In conclusion, the prevalence of SDB and sleep pattern of patients with Chagas' disease were similar to that of patients with CHF due to other etiologies. Males presented more frequent and more severe SDB and worse sleep quality than females. The presence of CSR while awake, but not during sleep, may be associated with a poor prognosis in patients with CHF.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000300007
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2008000300007
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.41 n.3 2008
Fonte: | info:eu-repo/semantics/openAccess