Data/hora: 04/06/2024 00:42:21

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Acute stress-induced antinociception is cGMP-dependent but heme oxygenase-independent
Autores: | Carvalho-Costa,P.G.; Branco,L.G.S.; Leite-Panissi,C.R.A.
Data: | 2014-12-01
Ano: | 2014
Palavras-chave: | Heme oxygenase; Carbon monoxide; CGMP; Lateral cerebral ventricle; Acute stress; Antinociception.
Resumo: | Endogenous carbon monoxide (CO), which is produced by the enzyme heme oxygenase (HO), participates as a neuromodulator in physiological processes such as thermoregulation and nociception by stimulating the formation of 3′,5′-cyclic guanosine monophosphate (cGMP). In particular, the acute physical restraint-induced fever of rats can be blocked by inhibiting the enzyme HO. A previous study reported that the HO-CO-cGMP pathway plays a key phasic antinociceptive role in modulating noninflammatory acute pain. Thus, this study evaluated the involvement of the HO-CO-cGMP pathway in antinociception induced by acute stress in male Wistar rats (250-300 g; n=8/group) using the analgesia index (AI) in the tail flick test. The results showed that antinociception induced by acute stress was not dependent on the HO-CO-cGMP pathway, as neither treatment with the HO inhibitor ZnDBPG nor heme-lysinate altered the AI. However, antinociception was dependent on cGMP activity because pretreatment with the guanylate cyclase inhibitor 1H-[1,2,4] oxadiazolo [4,3-a] quinoxaline-1-one (ODQ) blocked the increase in the AI induced by acute stress.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001201057
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431X20143926
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.47 n.12 2014
Fonte: | info:eu-repo/semantics/openAccess