Data/hora: 02/06/2024 03:46:29

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Frequency of CCR5delta32 in Brazilian populations
Autores: | Vargas,A.E.; Marrero,A.R.; Salzano,F.M.; Bortolini,M.C.; Chies,J.A.B.
Data: | 2006-03-01
Ano: | 2006
Palavras-chave: | CCR5; Chemokine receptors; Brazilian population; Gene flow.
Resumo: | A sample of 103 randomly chosen healthy individuals from Alegrete, RS, Brazil, was tested for the CCR5delta32 allele, which is known to influence susceptibility to HIV-1 infection. The CCR5delta32 allele was identified by PCR amplification using specific primers flanking the region of deletion, followed by electrophoresis on a 3% agarose gel. The data obtained were compared to those reported for other populations and interpreted in terms of Brazilian history. The individuals studied came from a highly admixed population. Most of them were identified as white (N = 59), while blacks and browns (mulattoes) were N = 13 and N = 31, respectively. The observed frequencies, considering the white, black and brown samples (6.8, 3.8, and 6.4%, respectively), suggest an important European parental contribution, even in populations identified as black and brown. However, in Brazil as a whole, this allele shows gradients indicating a relatively good correlation with the classification based on skin color and other physical traits, used here to define major Brazilian population groups.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000300002
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2006000300002
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.39 n.3 2006
Fonte: | info:eu-repo/semantics/openAccess