Data/hora: 09/06/2024 04:47:38

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Cytokines in innate and acquired immunity to Trypanosoma cruzi infection
Autores: | Abrahamsohn,I.A.
Data: | 1998-01-01
Ano: | 1998
Palavras-chave: | Trypanosoma cruzi; Interferon-gamma; Interleukin-12; TNF-alpha; Interleukin-10; Innate immunity; Knock-out mice.
Resumo: | Resistance to Trypanosoma cruzi infections is critically dependent on cytokine-mediated activation of cell-mediated immune effector mechanisms. This review focuses on the role of IL-10, TNF-&lt;FONT FACE="Symbol"&gt;a&lt;/font&gt;, IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; and IL-12 in controlling T. cruzi replication by the innate and specific immune systems of the vertebrate host. A study performed on mice with disrupted recombinase-activating genes (RAG/KO), which lack T and B lymphocytes, revealed the importance of IL-12, IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; and TNF-&lt;FONT FACE="Symbol"&gt;a&lt;/font&gt; in the resistance against T. cruzi mediated by the innate immune system. In addition, data from experiments using IL-10 KO, RAG/KO and double RAG/IL-10 KO mice indicating an in vivo regulatory role of IL-10 in innate and T. cruzi-specific immunity are discussed
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100015
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1998000100015
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.31 n.1 1998
Fonte: | info:eu-repo/semantics/openAccess