Data/hora: 10/06/2024 06:57:46

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Gap junction modulation by extracellular signaling molecules: the thymus model
Autores: | Alves,L.A.; Nihei,O.K.; Fonseca,P.C.; Campos-de-Carvalho,A.C.; Savino,W.
Data: | 2000-04-01
Ano: | 2000
Palavras-chave: | Thymus; Thymic epithelial cells; Connexin 43; Hormones; Interleukins.
Resumo: | Gap junctions are intercellular channels which connect adjacent cells and allow direct exchange of molecules of low molecular weight between them. Such a communication has been described as fundamental in many systems due to its importance in coordination, proliferation and differentiation. Recently, it has been shown that gap junctional intercellular communication (GJIC) can be modulated by several extracellular soluble factors such as classical hormones, neurotransmitters, interleukins, growth factors and some paracrine substances. Herein, we discuss some aspects of the general modulation of GJIC by extracellular messenger molecules and more particularly the regulation of such communication in the thymus gland. Additionally, we discuss recent data concerning the study of different neuropeptides and hormones in the modulation of GJIC in thymic epithelial cells. We also suggest that the thymus may be viewed as a model to study the modulation of gap junction communication by different extracellular messengers involved in non-classical circuits, since this organ is under bidirectional neuroimmunoendocrine control.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400012
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2000000400012
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.33 n.4 2000
Fonte: | info:eu-repo/semantics/openAccess