Data/hora: 02/06/2024 02:50:50

Provedor de dados: | 56
País: | Brazil
Título: | Myocardial ischemic preconditioning upregulated protein 1(Mipu1):zinc finger protein 667 - a multifunctional KRAB/C2H2 zinc finger protein
Autores: | Han,D.; Zhang,C.; Fan,W.J.; Pan,W.J.; Feng,D.M.; Qu,S.L.; Jiang,Z.S.
Data: | 2015-01-01
Ano: | 2015
Palavras-chave: | Mipu1; Zinc finger structure; Nuclear factor; Transcription and repression.
Resumo: | Myocardial ischemic preconditioning upregulated protein 1 (Mipu1) is a newly discovered upregulated gene produced in rats during the myocardial ischemic preconditioning process. Mipu1 cDNA contains a 1824-base pair open reading frame and encodes a 608 amino acid protein with an N-terminal Krüppel-associated box (KRAB) domain and classical zinc finger C2H2 motifs in the C-terminus. Mipu1 protein is located in the cell nucleus. Recent studies found that Mipu1 has a protective effect on the ischemia-reperfusion injury of heart, brain, and other organs. As a nuclear factor, Mipu1 may perform its protective function through directly transcribing and repressing the expression of proapoptotic genes to repress cell apoptosis. In addition, Mipu1 also plays an important role in regulating the gene expression of downstream inflammatory mediators by inhibiting the activation of activator protein-1 and serum response element.
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000100001
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20144029
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.48 n.1 2015
Fonte: | info:eu-repo/semantics/openAccess