Data/hora: 02/06/2024 01:16:06

Provedor de dados: 	56	
País: 	Brazil	
Título: 	In vitro antimicrobial activity of a new series of 1,4-naphthoquinones	
Autores: 	Riffel,A.; Medina,L.F.; Stefani,V.; Santos,R.C.; Bizani,D.; Brandelli,A.	
Data: 	2002-07-01	
Ano: 	2002	
Palavras-chave: 	5-Amino-8-hydroxy-1; 4-naphthoquinone Antimicrobial agent Staphylococcus aureus Quinone Naphthazarin 5-Acetamido-8-hydroxy-1; 4-naphthoquinone 2; 3-Diamino-1; 4-naphthoquinone.	
Resumo: 	The antibacterial activity of a series of 1,4-naphthoquinones was demonstrated. Disk diffusion tests were carried out against several Gram-positive and Gram-negative bacteria. The compound 5-amino-8-hydroxy-1,4-naphthoquinone was the most effective, presenting inhibition zones measuring 20 mm against staphylococci, streptococci and bacilli at 50 µg/ml. Methicillin-resistant Staphylococcus aureus and several clinical isolates of this bacterium were also inhibited. Naphthazarin, 5-acetamido-8-hydroxy-1,4-naphthoquinone, and 2,3-diamino-1,4-naphthoquinone were the next most active compounds. The minimal inhibitory concentration of the active compounds was determined against S. aureus, ranging from 30 to 125 µg/ml. All compounds presented a minimal bactericidal concentration higher than 500 µg/ml, indicating that their effect was bacteriostatic. The EC50, defined as the drug concentration that produces 50% of maximal effect, was 8 µg/ml for 5-amino-8-hydroxy-1,4-naphthoquinone against S. aureus, S. intermedius, and S. epidermidis. These results indicate an effective in vitro activity of 5-amino-8-hydroxy-1,4-naphthoquinone and encourage further studies for its application in antibiotic therapy.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000700008	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X2002000700008	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.35 n.7 2002	
Fonte: 	info:eu-repo/semantics/openAccess