Data/hora: 16/06/2024 07:52:39

Provedor de dados: | 56
País: | Brazil
Título: | In vitro antimicrobial activity of a new series of 1,4-naphthoquinones
Autores: | Riffel,A.; Medina,L.F.; Stefani,V.; Santos,R.C.; Bizani,D.; Brandelli,A.
Data: | 2002-07-01
Ano: | 2002
Palavras-chave: | 5-Amino-8-hydroxy-1; 4-naphthoquinone Antimicrobial agent Staphylococcus aureus Quinone Naphthazarin 5-Acetamido-8-hydroxy-1; 4-naphthoquinone 2; 3-Diamino-1; 4-naphthoquinone.
Resumo: | The antibacterial activity of a series of 1,4-naphthoquinones was demonstrated. Disk diffusion tests were carried out against several Gram-positive and Gram-negative bacteria. The compound 5-amino-8-hydroxy-1,4-naphthoquinone was the most effective, presenting inhibition zones measuring 20 mm against staphylococci, streptococci and bacilli at 50 µg/ml. Methicillin-resistant Staphylococcus aureus and several clinical isolates of this bacterium were also inhibited. Naphthazarin, 5-acetamido-8-hydroxy-1,4-naphthoquinone, and 2,3-diamino-1,4-naphthoquinone were the next most active compounds. The minimal inhibitory concentration of the active compounds was determined against S. aureus, ranging from 30 to 125 µg/ml. All compounds presented a minimal bactericidal concentration higher than 500 µg/ml, indicating that their effect was bacteriostatic. The EC50, defined as the drug concentration that produces 50% of maximal effect, was 8 µg/ml for 5-amino-8-hydroxy-1,4-naphthoquinone against S. aureus, S. intermedius, and S. epidermidis. These results indicate an effective in vitro activity of 5-amino-8-hydroxy-1,4-naphthoquinone and encourage further studies for its application in antibiotic therapy.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000700008
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2002000700008
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.35 n.7 2002
Fonte: | info:eu-repo/semantics/openAccess