Data/hora: 17/06/2024 14:14:12

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Prevalence of antibodies to human herpesvirus-8 in populations with and without risk for infection in São Paulo State	
Autores: 	Souza,V.A.U.F.; Sumita,L.M.; Freire,W.; Sato,H.K.; Grandi,J.L.; Pierrotti,L.C.; Nascimento,M.C.; Pannuti,C.S.	
Data: 	2004-01-01	
Ano: 	2004	
Palavras-chave: 	HHV-8; Seroprevalence; AIDS; Kaposi's sarcoma; Immunofluorescence assay; Latency-associated nuclear antigen; Lytic-phase antigens.	
Resumo: 	Human herpesvirus 8 (HHV-8) is a newly described herpesvirus that is etiologically associated with all forms of Kaposi's sarcoma (KS). Seroepidemiological studies have shown high prevalence rates of HHV-8 antibodies among men who have sex with men (MSM) and AIDS patients, African children, Brazilian Amerindians, and elderly individuals in certain regions of Europe. The aim of the present study was to determine the prevalence of HHV-8 antibodies in healthy children and young adults from different cities in São Paulo State, and in a population at high risk for HHV-8 infection: HIV-negative MSM, and AIDS patients with and without KS. Antibodies to HHV-8 latency-associated nuclear antigen and lytic-phase antigens were detected by immunofluorescence assays. In 643 healthy children and young adults from the general population attending a vaccination program for yellow fever in ten different cities in São Paulo State, the prevalence of HHV-8 antibodies detected by the presence of latent or lytic antigens ranged from 1.0 to 4.1% in the different age groups (mean = 2.5%). In the MSM group, the prevalence was 31/95 (32.6%). In the group of patients with AIDS, the prevalence was 39.2% (51/130) for non-KS patients and 98.7% (77/78) for AIDS patients with the diagnosis of KS confirmed by histopathological examination. We conclude that HHV-8 has a restricted circulation among healthy children and young adults in the general population of São Paulo State and a high prevalence among MSM and AIDS patients.	
Tipo: 	Info:eu-repo/semantics/other	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000100017	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X2004000100017	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.37 n.1 2004	
Fonte: 	info:eu-repo/semantics/openAccess