Data/hora: 16/06/2024 09:22:03

Provedor de dados: 	56	
País: 	Brazil	
Título: 	RNA and DNA aptamers as potential tools to prevent cell adhesion in disease	
Autores: 	Ulrich,H.; Alves,M.J.M.; Colli,W.	
Data: 	2001-03-01	
Ano: 	2001	
Palavras-chave: 	SELEX; Aptamers; Cell adhesion; Cell invasion; Trypanosoma cruzi.	
Resumo: 	Recent research has shown that receptor-ligand interactions between surfaces of communicating cells are necessary prerequisites for cell proliferation, cell differentiation and immune defense. Cell-adhesion events have also been proposed for pathological conditions such as cancer growth, metastasis, and host-cell invasion by parasites such as Trypanosoma cruzi. RNA and DNA aptamers (aptus = Latin, fit) that have been selected from combinatorial nucleic acid libraries are capable of binding to cell-adhesion receptors leading to a halt in cellular processes induced by outside signals as a consequence of blockage of receptor-ligand interactions. We outline here a novel approach using RNA aptamers that bind to T. cruzi receptors and interrupt host-cell invasion in analogy to existing procedures of blocking selectin adhesion and function in vitro and in vivo.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300002	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X2001000300002	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.34 n.3 2001	
Fonte: 	info:eu-repo/semantics/openAccess