Data/hora: 12/06/2024 03:37:40

Provedor de dados: | 56
País: | Brazil
Título: | Evaluation of 99mTc-HYNIC-βAla-Bombesin(7-14) as an agent for pancreas tumor detection in mice
Autores: | Carlesso,F.N.; Fuscaldi,L.L.; Araújo,R.S.; Teixeira,C.S.; Oliveira,M.C.; Fernandes,S.O.A.; Cassali,G.D.; Reis,D.C.; Barros,A.L.B.; Cardoso,V.N.
Data: | 2015-10-01
Ano: | 2015
Palavras-chave: | 99mTc-HYNIC-βAla-Bombesin; Capan-1; Scintigraphic images; Pancreas tumor; Biodistribution.
Resumo: | Pancreatic adenocarcinoma is important in oncology because of its high mortality rate. Deaths may be avoided if an early diagnosis could be achieved. Several types of tumors overexpress gastrin-releasing peptide receptors (GRPr), including pancreatic cancer cells. Thus, a radiolabeled peptide derivative of gastrin-releasing peptide (GRP) may be useful as a specific imaging probe. The purpose of the present study was to evaluate the feasibility of using99mTc-HYNIC-βAla-Bombesin(7-14)as an imaging probe for Capan-1 pancreatic adenocarcinoma. Xenographic pancreatic tumor was developed in nude mice and characterized by histopathological analysis. Biodistribution studies and scintigraphic images were carried out in tumor-bearing nude mice. The two methods showed higher uptake by pancreatic tumor when compared to muscle (used as control), and the tumor-to-muscle ratio indicated that99mTc-HYNIC-βAla-Bombesin(7-14)uptake was four-fold higher in tumor cells than in other tissues. Scintigraphic images also showed a clear signal at the tumor site. The present data indicate that99mTc-HYNIC-βAla-Bombesin(7-14)may be useful for the detection of pancreatic adenocarcinoma.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015001000010
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20154506
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.48 n.10 2015
Fonte: | info:eu-repo/semantics/openAccess