Data/hora: 11/06/2024 18:18:08

Provedor de dados: | 56
País: | Brazil
Título: | Effect of lead acetate on neurobehavioral development of rats
Autores: | Mello,C.F.; Kraemer,C.K.; Filippin,A.; Morsch,V.M.; Rodrigues,A.L.S.; Martins,A.F.; Rubin,M.A.
Data: | 1998-07-01
Ano: | 1998
Palavras-chave: | Lead; Neurobehavioral development; Undernutrition; Heavy metal intoxication; Teratology; Rat.
Resumo: | We investigated the effects of lead exposure during the pre- and postnatal period on the neurobehavioral development of female Wistar rats (70-75 days of age, 120-150 g) using a protocol of lead intoxication that does not affect weight gain. Wistar rats were submitted to lead acetate intoxication by giving their dams 1.0 mM lead acetate. Control dams received deionized water. Growth and neuromotor development were assessed by monitoring daily the following parameters in 20 litters: body weight, ear unfolding, incisor eruption, eye opening, righting, palmar grasp, negative geotaxis, cliff avoidance and startle reflex. Spontaneous alternation was assessed on postnatal day 17 using a T maze. The animals' ability to equilibrate on a beaker rim was measured on postnatal day 19. Lead intoxication was confirmed by measuring renal, hepatic and cerebral lead concentration in dams and litters. Lead treatment hastened the day of appearance of the following parameters: eye opening (control: 13.5 ± 0.6, N = 88; lead: 12.9 ± 0.6, N = 72; P&amp;lt;0.05), startle reflex (control: 13.0 ± 0.8, N = 88; lead: 12.0 ± 0.7, N = 72; P&amp;lt;0.05) and negative geotaxis. On the other hand, spontaneous alternation performance was hindered in lead-exposed animals (control: 37.6 ± 19.7; lead: 57.5 ± 28.3% of alternating animals; P&amp;lt;0.05). These results suggest that lead exposure without concomitant undernutrition alters rat development, affecting specific subsets of motor skills.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000700010
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1998000700010
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.31 n.7 1998
Fonte: | info:eu-repo/semantics/openAccess