Data/hora: 03/06/2024 02:54:27

Provedor de dados: | 56
País: | Brazil
Título: | Toxicity to sea urchin egg development of the quinone fraction obtained from Auxemma oncocalyx
Autores: | Costa-Lotufo,L.V.; Ferreira,M.A.D.; Lemos,T.L.G.; Pessoa,O.D.L.; Viana,G.S.B.; Cunha,G.M.A.
Data: | 2002-08-01
Ano: | 2002
Palavras-chave: | Auxemma oncocalyx; Quinones; Sea urchin eggs; Oncocalyxone A.
Resumo: | Auxemma oncocalyx Taub. belongs to the Boraginaceae family and is native to the Brazilian northeast where it is known as "pau-branco". We investigated the ability of the water soluble fraction isolated from the heartwood of A. oncocalyx to inhibit sea urchin egg development. This fraction contains about 80% oncocalyxone A (quinone fraction), a compound known to possess strong cytotoxic and antitumor activities. In fact, the quinone fraction inhibited cleavage in a dose-dependent manner [IC50 of 18.4 (12.4-27.2) µg/ml, N = 6], and destroyed the embryos in the blastula stage [IC50 of 16.2 (13.7-19.2) µg/ml, N = 6]. We suggest that this activity is due to the presence of oncocalyxone A. In fact, these quinones present in A. oncocalyx extract have strong toxicity related to their antimitotic activity.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000800010
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2002000800010
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.35 n.8 2002
Fonte: | info:eu-repo/semantics/openAccess