Data/hora: 04/06/2024 18:07:22

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Lamivudine therapy for hepatitis B in renal transplantation
Autores: | Santos,F.R.L.; Haiashi,A.R.; Araújo,M.R.T.; Abensur,H.; Romão Junior,J.E.; Noronha,I.L.
Data: | 2002-02-01
Ano: | 2002
Palavras-chave: | Lamivudine; Kidney transplantation; Hepatitis B.
Resumo: | Antiviral therapies are associated with an increased risk of acute rejection in transplant patients. The aim of the present study was to evaluate the efficacy and safety of lamivudine therapy for hepatitis B virus (HBV) infection in renal transplant patients. Six patients were included in this study. They received 150 mg/day of lamivudine during a follow-up period of 24 months. The laboratory tests monitored were HBV DNA, HBsAg, HBeAg, ALT, gamma-GT, serum creatinine and blood cyclosporine levels. The HBV DNA became undetectable in four patients as early as in the third month of treatment. After six months, the viral load was also negative in the other two patients, and remained so until 18 months of follow-up. The medication was well tolerated with no major side effects. Lamivudine was safe and effective in blocking HBV replication in renal transplant patients without any apparent increase in the risk of graft failure for the 24-month period of study.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000200008
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2002000200008
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.35 n.2 2002
Fonte: | info:eu-repo/semantics/openAccess