Data/hora: 11/06/2024 05:38:45

Provedor de dados: | 56
País: | Brazil
Título: | Acute effect of passive cycle-ergometry and functional electrical stimulation on nitrosative stress and inflammatory cytokines in mechanically ventilated critically ill patients: a randomized controlled trial
Autores: | França,E.E.T.; Gomes,J.P.V.; De Lira,J.M.B.; Amaral,T.C.N.; Vilaça,A.F.; Paiva Júnior,M.D.S.; Elihimas Júnior,U.F.; Correia Júnior,M.A.V.; Forgiarini Júnior,L.A.; Costa,M.J.C.; Andrade,M.A.; Ribeiro,L.C.; De Castro,C.M.M.B.
Data: | 2020-01-01
Ano: | 2020
Palavras-chave: | Cytokines; Nitrosative stress; Intensive care unit; Physiotherapy.
Resumo: | Early mobilization is beneficial for critically ill patients because it reduces muscle weakness acquired in intensive care units. The objective of this study was to assess the effect of functional electrical stimulation (FES) and passive cycle ergometry (PCE) on the nitrous stress and inflammatory cytometry in critically ill patients. This was a controlled, randomized, open clinical trial carried out in a 16-bed intensive care unit. The patients were randomized into four groups: Control group (n=10), did not undergo any therapeutic intervention during the study; PCE group (n=9), lower-limb PCE for 30 cycles/min for 20 min; FES group (n=9), electrical stimulation of quadriceps muscle for 20 min; and FES with PCE group (n=7), patients underwent PCE and FES, with their order determined randomly. The serum levels of nitric oxide, tumor necrosis factor alpha, interferon gamma, and interleukins 6 and 10 were analyzed before and after the intervention. There were no differences in clinical or demographic characteristics between the groups. The results revealed reduced nitric oxide concentrations one hour after using PCE (P&lt;0.001) and FES (P&lt;0.05), thereby indicating that these therapies may reduce cellular nitrosative stress when applied separately. Tumor necrosis factor alpha levels were reduced after the PCE intervention (P=0.049). PCE and FES reduced nitric oxide levels, demonstrating beneficial effects on the reduction of nitrosative stress. PCE was the only treatment that reduced the tumor necrosis factor alpha concentration.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000400605
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20208770
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.53 n.4 2020
Fonte: | info:eu-repo/semantics/openAccess