Data/hora: 10/06/2024 07:48:25

Provedor de dados: | 56
País: | Brazil
Título: | Anxiolytic-like effects of 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate in mice
Autores: | Rubin,M.A.; Albach,C.A.; Berlese,D.B.; Bonacorso,H.G.; Bittencourt,S.R.T.; Queiroz,C.M.T.; Maixner,A.E.; Mello,C.F.
Data: | 2000-09-01
Ano: | 2000
Palavras-chave: | Anxiolytic 1; 5-benzodiazepine diazepam elevated plus-maze holeboard picrotoxin.
Resumo: | The pharmacological effects of 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate (PTMB), a novel synthetic benzodiazepine, were examined in mice. In the elevated plus-maze test of anxiety, 0.3-1 mg/kg diazepam ip (F(3,53) = 3.78; P&lt;0.05) and 1-10 mg/kg PTMB ip increased (F(5,98) = 3.26; P&lt;0.01), whereas 2 mg/kg picrotoxin ip decreased (F(3,59) = 8.32; P&lt;0.001) the proportion of time spent in the open arms, consistent with an anxiolytic action of both benzodiazepines, and an anxiogenic role for picrotoxin. In the holeboard, 1.0 mg/kg diazepam ip increased (F(3,54) = 2.78; P&lt;0.05) and 2 mg/kg picrotoxin ip decreased (F(3,59) = 4.69; P&lt;0.01) locomotor activity. Rotarod assessment revealed that 1 mg/kg diazepam ip and 3, 10 and 30 mg/kg PTMB ip produced significant motor incoordination compared to vehicle control (F(4,70) = 7.6; P&lt;0.001). These data suggest that the recently synthesized PTMB compound possesses anxiolytic activity and produces motor incoordination similar to those observed with diazepam.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900013
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2000000900013
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.33 n.9 2000
Fonte: | info:eu-repo/semantics/openAccess