Data/hora: 12/06/2024 11:49:29

Provedor de dados: 	Brazilian Journal of Medical and Biological Research	
País: 	Brazil	
Título: 	Anxiolytic-like effects of 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate in mice	
Autores: 	Rubin,M.A.; Albach,C.A.; Berlese,D.B.; Bonacorso,H.G.; Bittencourt,S.R.T.; Queiroz,C.M.T.; Maixner,A.E.; Mello,C.F.	
Data: 	2000-09-01	
Ano: 	2000	
Palavras-chave: 	Anxiolytic 1; 5-benzodiazepine diazepam elevated plus-maze holeboard picrotoxin.	
Resumo: 	The pharmacological effects of 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate (PTMB), a novel synthetic benzodiazepine, were examined in mice. In the elevated plus-maze test of anxiety, 0.3-1 mg/kg diazepam ip (F(3,53) = 3.78; P&lt;0.05) and 1-10 mg/kg PTMB ip increased (F(5,98) = 3.26; P&lt;0.01), whereas 2 mg/kg picrotoxin ip decreased (F(3,59) = 8.32; P&lt;0.001) the proportion of time spent in the open arms, consistent with an anxiolytic action of both benzodiazepines, and an anxiogenic role for picrotoxin. In the holeboard, 1.0 mg/kg diazepam ip increased (F(3,54) = 2.78; P&lt;0.05) and 2 mg/kg picrotoxin ip decreased (F(3,59) = 4.69; P&lt;0.01) locomotor activity. Rotarod assessment revealed that 1 mg/kg diazepam ip and 3, 10 and 30 mg/kg PTMB ip produced significant motor incoordination compared to vehicle control (F(4,70) = 7.6; P&lt;0.001). These data suggest that the recently synthesized PTMB compound possesses anxiolytic activity and produces motor incoordination similar to those observed with diazepam.	
Tipo: 	Info:eu-repo/semantics/other	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900013	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X2000000900013	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.33 n.9 2000	
Fonte: 	info:eu-repo/semantics/openAccess