Data/hora: 03/06/2024 02:21:38

Provedor de dados: | Brazilian Journal of Microbiology
País: | Brazil
Título: | Effect of alcohols on filamentation, growth, viability and biofilm development in Candida albicans
Autores: | Chauhan,Nitin M; Shinde,Ravikumar B; Karuppayil,S. Mohan.
Data: | 2013-12-01
Ano: | 2013
Palavras-chave: | Alcohols; Signalling; Morphogenesis; Biofilms; Yeast metabolism; Candida albicans.
Resumo: | In this study we report the potential of alcohols as morphogenetic regulators in Candida albicans. All the alcohols tested influenced various modes of growth like planktonic as well as biofilm forms. Viability was affected at high concentrations. Among the alcohols, the response of C. albicans to amyl alcohol (pentanol) was noteworthy. Amyl alcohol at a concentration 0.5% which was not inhibitory to growth and viability specifically inhibited morphogenetic switching from yeast to hyphal forms. It also inhibited normal biofilm development favoring yeast dominated biofilms. Based on this study we hypothesize that alcohols produced under anaerobic conditions may not favor biofilm development and support dissemination of yeast cells. Since anaerobic conditions are not found to favor production of quorum sensing molecules like farnesol, the alcohols may play a role in morphogenetic regulation.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000400041
Editor: | Sociedade Brasileira de Microbiologia
Relação: | 10.1590/S1517-83822014005000012
Formato: | text/html
Fonte: | Brazilian Journal of Microbiology  v.44 n.4 2013
Fonte: | info:eu-repo/semantics/openAccess