Data/hora: 09/06/2024 07:21:14

Provedor de dados: | Brazilian Journal of Microbiology
País: | Brazil
Título: | Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction
Autores: | Sá,Marcus Mandolesi; Ferreira,Misael; Lima,Emerson Silva; Santos,Ivanildes dos; Orlandi,Patrícia Puccinelli; Fernandes,Luciano.
Data: | 2014-09-01
Ano: | 2014
Palavras-chave: | Antimicrobial; Allylic thiocyanate; Morita-Baylis-Hillman reaction; MRSA.
Resumo: | Bacterial resistance to commonly used antibiotics has been recognized as a significant global health issue. In this study, we carried out the screening of a family of allylic thiocyanates for their action against a diversity of bacteria and fungi with a view to developing new antimicrobial agents. Allylic thiocyanates bearing halogenated aryl groups, which were readily obtained in two steps from the Morita-Baylis-Hillman adducts, showed moderate-to-high activity against selective pathogens, including a methicillin-resistant S. aureus (MRSA) strain. In particular cases, methyl (Z)-3-(2,4-dichlorophenyl)-2-(thiocyanomethyl)-2-propenoate exhibited antimicrobial activity comparable to the reference antibiotic Imipenem.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000300007
Editor: | Sociedade Brasileira de Microbiologia
Relação: | 10.1590/S1517-83822014000300007
Formato: | text/html
Fonte: | Brazilian Journal of Microbiology  v.45 n.3 2014
Fonte: | info:eu-repo/semantics/openAccess