Data/hora: 16/06/2024 09:19:56

Provedor de dados: 	Brazilian Journal of Microbiology	
País: 	Brazil	
Título: 	Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction	
Autores: 	Sá,Marcus Mandolesi; Ferreira,Misael; Lima,Emerson Silva; Santos,Ivanildes dos; Orlandi,Patrícia Puccinelli; Fernandes,Luciano.	
Data: 	2014-09-01	
Ano: 	2014	
Palavras-chave: 	Antimicrobial; Allylic thiocyanate; Morita-Baylis-Hillman reaction; MRSA.	
Resumo: 	Bacterial resistance to commonly used antibiotics has been recognized as a significant global health issue. In this study, we carried out the screening of a family of allylic thiocyanates for their action against a diversity of bacteria and fungi with a view to developing new antimicrobial agents. Allylic thiocyanates bearing halogenated aryl groups, which were readily obtained in two steps from the Morita-Baylis-Hillman adducts, showed moderate-to-high activity against selective pathogens, including a methicillin-resistant S. aureus (MRSA) strain. In particular cases, methyl (Z)-3-(2,4-dichlorophenyl)-2-(thiocyanomethyl)-2-propenoate exhibited antimicrobial activity comparable to the reference antibiotic Imipenem.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000300007	
Editor: 	Sociedade Brasileira de Microbiologia	
Relação: 	10.1590/S1517-83822014000300007	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Microbiology  v.45 n.3 2014	
Fonte: 	info:eu-repo/semantics/openAccess