Data/hora: 12/06/2024 14:17:06

Provedor de dados: | Brazilian Journal of Microbiology
País: | Brazil
Título: | HIV-1 anti-retroviral drug effect on the C. albicans hyphal growth rate by a Bio-Cell Tracer system
Autores: | Melo,Nadja Rodrigues de; Vilela,Maria Marluce Santos; Jorge Junior,Jacks; Kamei,Katsuhiko; Miyaji,Makoto; Fukushima,Kazutaka; Nishimura,Kazuko; Groeneveld,Philip; Kelly,Steven L.; Taguchi,Hideaki.
Data: | 2006-09-01
Ano: | 2006
Palavras-chave: | Candida; Hyphal; Protease inhibitor.
Resumo: | Declining incidence of oropharyngeal candidosis and opportunistic infections over recent years can be attributed to the use of highly active anti-retroviral therapy (HAART). Infection with C. albicans generally involves adherence and colonization of superficial tissues. During this process, budding yeasts are able to transform to hyphae and penetrate into the deep tissue. Using the biocell tracer system, C. albicans hyphal growth was dynamically observed at the cellular level. Ritonavir was effective in the inhibition of hyphal growth with growth rate of 0.8 mum/min. This study showed the in vitro effect of HIV anti-retroviral drug on the growth rate of the C. albicans hyphae.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822006000300006
Editor: | Sociedade Brasileira de Microbiologia
Relação: | 10.1590/S1517-83822006000300006
Formato: | text/html
Fonte: | Brazilian Journal of Microbiology  v.37 n.3 2006
Fonte: | info:eu-repo/semantics/openAccess