Data/hora: 05/06/2024 18:31:02

Provedor de dados: 	58	
País: 	Brazil	
Título: 	Response surface methodology for optimization of production of lovastatin by solid state fermentation	
Autores: 	Pansuriya,Ruchir C.; Singhal,Rekha S.	
Data: 	2010-03-01	
Ano: 	2010	
Palavras-chave: 	Lovastatin; Response surface methodology; Solid state fermentation; Aspergillus terreus.	
Resumo: 	Lovastatin, an inhibitor of HMG-CoA reductase, was produced by solid state fermentation (SSF) using a strain of Aspergillus terreus UV 1718. Different solid substrates and various combinations thereof were evaluated for lovastatin production. Wheat bran supported the maximum production (1458 ± 46 µg g-1 DFM) of lovastatin. Response surface methodology (RSM) was applied to optimize the medium constituents. A 2(4) full-factorial central composite design (CCD) was chosen to explain the combined effects of the four medium constituents, viz. moisture content, particle size of the substrate, di-potassium hydrogen phosphate and trace ion solution concentration. Maximum lovastatin production of 2969 µg g-1 DFM was predicted by the quadratic model which was verified experimentally to be 3004 ± 25 µg g-1 DFM. Further RSM optimized medium supplemented with mycological, peptone supported highest yield of 3723.4±49 µg g-1 DFM. Yield of lovastatin increased 2.6 fold as with compared to un-optimized media.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822010000100024	
Editor: 	Sociedade Brasileira de Microbiologia	
Relação: 	10.1590/S1517-83822010000100024	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Microbiology  v.41 n.1 2010	
Fonte: 	info:eu-repo/semantics/openAccess