Data/hora: 02/06/2024 06:31:07

Provedor de dados: 	58	
País: 	Brazil	
Título: 	Synergistic effects of tacrolimus and azole antifungal compounds in fluconazole-susceptible and fluconazole-resistant Candida glabrata isolates	
Autores: 	Denardi,Laura Bedin; Mario,Débora Alves Nunes; Loreto,Érico Silva; Santurio,Janio Morais; Alves,Sydney Hartz.	
Data: 	2015-03-01	
Ano: 	2015	
Palavras-chave: 	Candida glabrata; Azole resistance; FK506; Combination therapy.	
Resumo: 	In vitro interaction between tacrolimus (FK506) and four azoles (fluconazole, ketoconazole, itraconazole and voriconazole) against thirty clinical isolates of both fluconazole susceptible and -resistant Candida glabrata were evaluated by the checkerboard microdilution method. Synergistic, indifferent or antagonism interactions were found for combinations of the antifungal agents and FK506. A larger synergistic effect was observed for the combinations of FK506 with itraconazole and voriconazole (43%), followed by that of the combination with ketoconazole (37%), against fluconazole-susceptible isolates. For fluconazole-resistant C. glabrata, a higher synergistic effect was obtained from FK506 combined with ketoconazole (77%), itraconazole (73%), voriconazole (63%) and fluconazole (60%). The synergisms that we observed in vitro, notably against fluconazole-resistant C. glabrata isolates, are promising and warrant further analysis of their applications in experimental in vivo studies.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000100125	
Editor: 	Sociedade Brasileira de Microbiologia	
Relação: 	10.1590/S1517-838246120120442	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Microbiology  v.46 n.1 2015	
Fonte: 	info:eu-repo/semantics/openAccess