Data/hora: 10/06/2024 02:58:30

Provedor de dados: 	Brazilian Journal of Microbiology	
País: 	Brazil	
Título: 	Helicobacter pylori with East Asian-type cagPAI genes is more virulent than strains with Western-type in some cagPAI genes	
Autores: 	Yuan,Xiao-yan; Yan,Jin-Jun; Yang,Ya-chao; Wu,Chun-mei; Hu,Yan; Geng,Jian-li.	
Data: 	2017-06-01	
Ano: 	2017	
Palavras-chave: 	Helicobacter pylori; CagPAI; Virulence; IL-8.	
Resumo: 	Abstract The severity of Helicobacter pylori-related disease is correlated with the presence and integrity of a cag pathogenicity island (cagPAI). cagPAI genotype may have a modifying effect on the pathogenic potential of the infecting strain. After analyzing the sequences of cagPAI genes, some strains with the East Asian-type cagPAI genes were selected for further analysis to examine the association between the diversity of the cagPAI genes and the virulence of H. pylori. The results showed that gastric mucosal inflammatory cell infiltration was significantly higher in patients with East Asian-type cagPAI genes H. pylori strain compared with mosaicism cagPAI genes H. pylori strain (p &lt; 0.05). H. pylori strains with the East Asian-type cagPAI genes were closely associated with IL-8 secretion in vitro and in vivo compared with H. pylori strains with the mosaicism cagPAI genes (p &lt; 0.01). H. pylori strains with East Asian-type cagPAI genes are able to strongly translocate CagA to host cells. These results suggest that H. pylori strains with East Asian-type cagPAI genes are more virulent than the strains of cagPAI gene/genes that are Western type.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822017000200218	
Editor: 	Sociedade Brasileira de Microbiologia	
Relação: 	10.1016/j.bjm.2016.12.004	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Microbiology  v.48 n.2 2017	
Fonte: 	info:eu-repo/semantics/openAccess