Data/hora: 12/06/2024 13:56:08

Provedor de dados: 	58	
País: 	Brazil	
Título: 	Novel nonsense mutation in the katA gene of a catalase-negative Staphylococcus aureus strain	
Autores: 	Lagos,Jaime; Alarcón,Pedro; Benadof,Dona; Ulloa,Soledad; Fasce,Rodrigo; Tognarelli,Javier; Aguayo,Carolina; Araya,Pamela; Parra,Bárbara; Olivares,Berta; Hormazábal,Juan Carlos; Fernández,Jorge.	
Data: 	2016-03-01	
Ano: 	2016	
Palavras-chave: 	Staphylococcus aureus; Catalase-negative; Catalase gene; KatA.	
Resumo: 	Abstract We report the first description of a rare catalase-negative strain of Staphylococcus aureus in Chile. This new variant was isolated from blood and synovial tissue samples of a pediatric patient. Sequencing analysis revealed that this catalase-negative strain is related to ST10 strain, which has earlier been described in relation to S. aureus carriers. Interestingly, sequence analysis of the catalase gene katA revealed presence of a novel nonsense mutation that causes premature translational truncation of the C-terminus of the enzyme leading to a loss of 222 amino acids. Our study suggests that loss of catalase activity in this rare catalase-negative Chilean strain is due to this novel nonsense mutation in the katA gene, which truncates the enzyme to just 283 amino acids.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000100177	
Editor: 	Sociedade Brasileira de Microbiologia	
Relação: 	10.1016/j.bjm.2015.11.012	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Microbiology  v.47 n.1 2016	
Fonte: 	info:eu-repo/semantics/openAccess