Data/hora: 08/06/2024 15:35:31

Provedor de dados: 	58	
País: 	Brazil	
Título: 	DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population	
Autores: 	Silva,Ronaldo Celerino da; Cruz,Heidi Lacerda Alves da; Brandão,Lucas André Cavalcanti; Guimarães,Rafael Lima; Montenegro,Lilian Maria Lapa; Schindler,Haiana Charifker; Segat,Ludovica; Crovella,Sergio.	
Data: 	2016-06-01	
Ano: 	2016	
Palavras-chave: 	Tuberculosis; Innate immunity; DEFB1; Genotyping; Polymorphism.	
Resumo: 	Abstract β-Defensin-1, an antimicrobial peptide encoded by the DEFB1 gene, is known to play an important role in lung mucosal immunity. In our association study we analyzed three DEFB1 functional polymorphisms -52G&gt;A (rs1799946), -44C&gt;G (rs1800972) and -20G&gt;A (rs11362) in 92 tuberculosis patients and 286 healthy controls, both from Northeast Brazil: no association was found between the studied DEFB1 polymorphisms and the disease. However we cannot exclude that this lack of association could be due to the low number of subjects analyzed, as suggested by the low statistical power achieved for the three analyzed SNPs (values between 0.16 and 0.50).	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000200389	
Editor: 	Sociedade Brasileira de Microbiologia	
Relação: 	10.1016/j.bjm.2015.09.001	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Microbiology  v.47 n.2 2016	
Fonte: 	info:eu-repo/semantics/openAccess