Data/hora: 02/06/2024 11:51:10

Provedor de dados: 	58	
País: 	Brazil	
Título: 	Employing pharmacokinetic and pharmacodynamic principles to optimize antimicrobial treatment in the face of emerging resistance	
Autores: 	Santos Filho,Lauro; Kuti,Joseph L.; Nicolau,David P.	
Data: 	2007-06-01	
Ano: 	2007	
Palavras-chave: 	Antibiotic; Bacteria; Pharmacodynamics; Resistance.	
Resumo: 	Antimicrobial efficacy in vivo is not exclusively defined by the activity of an antibiotic as determined in the in vitro susceptibility test. Knowledge of the pharmacokinetics and pharmacodynamics of antimicrobials and all phenomena occurring between antimicrobial agents and microorganisms is imperative. The pharmacodynamic (PD) parameters most often used in studies of antibiotic effect include the following relationships: the maximum free concentration (fCmax) to minimum inhibitory concentration (MIC) ratio, the free area under the curve (fAUC/MIC) ratio and the duration of time the free concentration exceeds the MIC (fT&gt;MIC). Utilization of known pharmacokinetic/ pharmacodynamic surrogate relationships should help to optimize treatment outcome, especially in the face of emerging resistance among Gram-positive and Gram-negative bacteria. Clinical studies in the field of antibacterial PD are still relatively scarce, and much information is needed to enable relevant dosing strategies for all types of antibiotics against all common infections and microorganisms. In this review, the distinctive patterns of antimicrobial activitybased on PD parameters are discussed. Various antibioticsand bacterial pathogens can be used as models to demonstrate the utilityof PD parameters in predicting the in vivo efficacy of antimicrobialtherapy. And finally, the use of computer modeling with Monte Carlo populationsimulations can further enhance the predictability of antimicrobial efficacywhen using PD parameters.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822007000200001	
Editor: 	Sociedade Brasileira de Microbiologia	
Relação: 	10.1590/S1517-83822007000200001	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Microbiology  v.38 n.2 2007	
Fonte: 	info:eu-repo/semantics/openAccess