Data/hora: 04/06/2024 01:24:27

Provedor de dados: 	60	
País: 	Brazil	
Título: 	Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius	
Autores: 	Cardoso,Priscylla Maria Martins; Mazuco,Renata Alves; Macedo,Lucas Soares Dazzi; Polese,Ariele Abreu Venturini; Barroso,Maria Eduarda de Souza; Baratella,Waléria Gramilich; Andrade,Tadeu Uggere de; Lenz,Dominik; Pereira,Thiago de Melo Costa; Endringer,Denise Coutinho.	
Data: 	2020-01-01	
Ano: 	2020	
Palavras-chave: 	Nephroprotection; Euterpe edulis Martius; Polyphenols; Anthocyanins; Antioxidant activity.	
Resumo: 	Contrast-induced nephropathy (NIC) is directly related to increased morbidity and mortality, and its treatment and prevention might be achieved by the administration of antioxidant products. The juçara palmetto (Euterpe edulis Martius) has fruits rich in phenolic compounds, which are known for their antioxidant activity. This work aimed to evaluate the nephroprotective activity of E. edulis pulp in the NIC animal model. The collected fruits were pulped, their contents of polyphenols and anthocyanins were quantified, and their antioxidant activity were evaluated. The nephroprotective effects were determined based on iodine contrast induction and evaluated by biochemical and histological analyses. The results showed that E. edulis pulp was rich in polyphenols (811 ± 16.7 mg EAG/g) and anthocyanins (181.25 mg/100 g) and had very strong antioxidant activity, as demonstrated by the DPPH (2,2-diphenyl-1-picryl-hydrazyl) method, which revealed an antioxidant activity index (AAI) of 3.4, and the 2,29-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method, which revealed an IC50 of 0.59 ± 0.03 mg/mL. In the in vivo experiments, E. edulis pulp tended to provide renal protection and reduce renal dysfunction and tubular morphological lesions in mice after the induction of NIC, and these effects were obtained through the antioxidant activities of the polyphenols in the pulp.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100522	
Editor: 	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas	
Relação: 	10.1590/s2175-97902019000318051	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Pharmaceutical Sciences  v.56 2020	
Fonte: 	info:eu-repo/semantics/openAccess