Data/hora: 16/06/2024 00:23:00

Provedor de dados: | 60
País: | Brazil
Título: | Gastric-resistant isoniazid pellets reduced degradation of rifampicin in acidic medium
Autores: | Freire,Fátima Duarte; Câmara,Manuela Bernardo; Dantas,Monique Gomes; Aragão,Cícero Flávio Soares; Lima e Moura,Túlio Flávio Accioly de; Rafﬁn,Fernanda Nervo.
Data: | 2014-12-01
Ano: | 2014
Palavras-chave: | Rifampicin; Gastric-resistant isoniazids/pellets; Pellets/enteric coating; Acrycoat L 100(r)/use/enteric coating.
Resumo: | Isoniazid and rifampicin are considered the first-line medication for preventing and treating tuberculosis. Rifampicin is degraded in the stomach acidic environment, especially when combined with isoniazid, factor contributing to treatment failure. In this study, gastric-resistant isoniazid pellets were obtained to physical contact of this drug with rifampicin and to bypass the stomach´s acidic environment. The pellets were fabricated using the extrusion-spheronization technique. The coating process was conducted in a fluid spray coater using Acrycoat L 100(r) solution as the coating agent. The pellets obtained were submitted to a dissolution test in HCl 0.1 N and phosphate buffer media. The results indicated that optimum gastric-resistance was only attained with the highest amount of coating material, with isoniazid almost fully released in phosphate buffer. The amount of rifampicin released from its mixture with non-coated isoniazid pellets in HCl 0.1 N was less than that released from its mixture with the enteric-coated pellets. Acrycoat L 100(r) was shown to be an effective enteric/gastric-resistant coating since the stability of rifampicin appeared to be enhanced when physical contact of this drug with isoniazid was prevented at low pH.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400749
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502014000400010
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.50 n.4 2014
Fonte: | info:eu-repo/semantics/openAccess