Data/hora: 11/06/2024 04:03:43

Provedor de dados: | 60
País: | Brazil
Título: | Enhancing the aqueous solubility and dissolution of olanzapine using freeze-drying
Autores: | Dixit,Mudit; Kini,Ashwini Gopalkrishna; Kulkarni,Parthasarthi Keshavarao.
Data: | 2011-12-01
Ano: | 2011
Palavras-chave: | Freeze-dried tablets/development; Olanzapine/freeze-dried tablets; Olanzapine/solubility; Olanzapine/stability; Olanzapine/dissolution; Freeze-drying.
Resumo: | The aim of the present study was to develop an olanzapine freeze-dried tablet (FDT). The solubility and dissolution rate of poorly water-soluble olanzapine was improved by preparing a freeze-dried tablet of olanzapine using the freeze-drying technique . The FDT was prepared by dispersing the drug in an aqueous solution of highly water-soluble carrier materials consisting of gelatin, glycine, and sorbitol. The mixture was poured in to the pockets of blister packs and then was subjected to freezing and lyophilisation. The FDT was characterised by DSC, XRD and SEM and was evaluated for saturation solubility and dissolution. The samples were stored in a stability chamber to investigate their physical stability. Results obtained by DSC and X-ray were analysed and showed the crystalline state of olanzapine in FDT transformation to the amorphous state during the formation of FDT. Scanning electron microscope (SEM) results suggest reduction in olanzapine particle size. The solubility of olanzapine from the FDT was observed to be nearly four and a half times greater than the pure drug. Results obtained from dissolution studies showed that olanzapine FDT significantly improved the dissolution rate of the drug compared with the physical mixture (PM) and the pure drug. More than 90% of olanzapine in FDT dissolved within 5 minutes, compared to only 19.78% of olanzapine pure drug dissolved over the course of 60 minutes. In a stability test, the release profile of the FDT was unchanged, as compared to the freshly prepared FDT after 90 days of storing.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400011
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502011000400011
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.47 n.4 2011
Fonte: | info:eu-repo/semantics/openAccess