Data/hora: 04/06/2024 03:03:03

Provedor de dados: 	60	
País: 	Brazil	
Título: 	Microemulsion based on Pterodon emarginatus oil and its anti-inflammatory potential	
Autores: 	Pascoa,Henrique; Diniz,Danielle Guimarães Almeida; Florentino,Iziara Ferreira; Costa,Elson Alves; Bara,Maria Teresa Freitas.	
Data: 	2015-03-01	
Ano: 	2015	
Palavras-chave: 	Pterodon emarginatus; Pterodon emarginatus; Medicinal plants; Microemulsion; Phytomedicine; Pharmaceutical technology.	
Resumo: 	This article reports the development of a pharmaceutical product containing vegetable actives from a Brazilian medicinal plant. The possibility of forming a microemulsion using Pterodon emarginatus ("sucupira") oil was evaluated and the anti-inflammatory potential of this microemulsion was also examined. A formulation was developed using P. emarginatus oil, a mixture of ethoxylated Castor Oil (Ultramone(r) R-540/propylene glycol 2:1) (surfactant/cosurfactant) and distilled water at a ratio of 10:15:75, respectively. The microemulsion which was selected was then subjected to the preliminary stability test and analyzed in terms of average diameter of droplets, pH, zeta potential, and polydispersity index, on the 1st, 7th, 15th, and 30th days after preparation and stored at different temperatures (5 ± 2 °C, 25 ± 2 °C, and 40 ± 2 °C). The anti-inflammatory in vivo activity of both oil and formulation were evaluated, using the experimental model of croton oil-induced ear edema. The preliminary stability test showed that the microemulsion stored at 5 and 25 °C retained its original features throughout the 30-day period. The anti-inflammatory potential of both oil and formulation was shown to be statistically significant (p &lt; 0.001), when compared to the control group, however, the microemulsion proved to be more effective (p &lt; 0.05) than the oil when applied directly to the ear.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100117	
Editor: 	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas	
Relação: 	10.1590/S1984-82502015000100013	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Pharmaceutical Sciences  v.51 n.1 2015	
Fonte: 	info:eu-repo/semantics/openAccess