Data/hora: 03/06/2024 16:44:21

Provedor de dados: | 60
País: | Brazil
Título: | Anticonvulsant profile of 2-ethylthio-7-methyl-4-(4-methylphenyl)pyrazolo[1,5-a][1,3,5]triazine
Autores: | Estrada,Martín Hermógenes; Insuasty,Henry; Cuca,Luis Enrique; Marder,Mariel; Fierro,Angélica; Guerrero,Mario Francisco.
Data: | 2014-03-01
Ano: | 2014
Palavras-chave: | Pyrazolo-triazine/anticonvulsant profile; Anticonvulsants/experimental study; Monoamine oxidase/inhibitors.
Resumo: | This work evaluates the central nervous effects in ICR strain mice of 2-ethylthio-7-methyl-4-(4-methylphenyl)pyrazolo[1,5-a][1,3,5]triazine (MH4b1), a compound obtained by an efficient one-step reaction of S,S-diethyl 4-methylbenzoylimidodithiocarbonate with 5-amino-3-methyl-1H-pyrazole, in order to assess its neuro-pharmacological profile. The tests applied were: maximal electroshock seizure (MES), pentylenetetrazole (PTZ) seizures, forced swimming, plus maze, marble burying, sleeping time, rota-rod and catalepsy. In addition, MH4b1 binding to the benzodiazepine site of the GABA-A receptor and MH4b1 inhibition of monoamine oxidase (MAO) subtypes A and B were evaluated. MH4b1 showed anticonvulsant effects in a dose dependent manner (30-300 mg/kg, p.o.) against MES and inhibition of MAO-B (IC50: 24.5 µM) without activity at the benzodiazepine site. These data suggest that MH4b1 has anticonvulsant properties related to MAO-B inhibition.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100007
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502011000100007
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.50 n.1 2014
Fonte: | info:eu-repo/semantics/openAccess