Data/hora: 09/06/2024 12:40:50

Provedor de dados: | 60
País: | Brazil
Título: | Lack of effect of cell-wall targeted antibacterials on biofilm formation and antifungal susceptibility of Candidaspecies
Autores: | Leite,Gisela Myrian de Lima; Baeza,Lílian Cristiane; Ramos,Rosana Teixeira; Yamada,Sérgio Seiji; Magon,Thiago Ferreira dos Santos; Kimura,Elza; Svidzinski,Terezinha Inez Estivalet.
Data: | 2014-09-01
Ano: | 2014
Palavras-chave: | Central venous cateter/use; Candidemia/control; Biofilm/formation; Antibacterials; Antifungals; Candida/species/control.
Resumo: | The use of central venous catheters (CVC) and broad-spectrum antibacterials are among the main risk factors for the development of candidemia in patients admitted to intensive care units (ICU). It is known that some antibacterials increase the resistance of these yeasts to azole antifungals. Thus, the aim of this research was to determine whether yeast present in CVC colonizations previously exposed to cell-wall targeted antibacterials benefit from a reduction in susceptibility to fluconazole and voriconazole, facilitating their ability to form biofilms. Candida albicans, C. tropicalis, C. glabrata, C. parapsilosis and C. guilhermondii were seeded into antibacterial (cefepime, meropenem, vancomycin, and piperacillin-tazobactam) gradient plates produced in Mueller-Hinton Agar. The susceptibility to fluconazole and voriconazole and the biofilm formation of the yeasts were tested before and after exposure to the antibacterials. None of the antibacterials exerted a significant effect on the in vitro susceptibility of the yeasts to the antifungal agents or on their ability to form biofilms. These results suggest that increased candidemia in ICU patients is not attributable to possible alterations in the yeasts, but is more likely caused by a weakening of the patient's general condition after long exposure to infection.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300467
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502014000300004
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.50 n.3 2014
Fonte: | info:eu-repo/semantics/openAccess