Data/hora: 09/06/2024 18:32:37

Provedor de dados: | 60
País: | Brazil
Título: | Determination of phytoconstituents of n-hexane extract of leaves of Morus nigra and evaluation of their effects on biochemical and histopathological parameters in paracetamol intoxicated mice liver
Autores: | Mallhi,Tauqeer Hussain; Qadir,Muhammad Imran; Khan,Yusra Habib.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | Moraceae; HPLC; Quercetin; Morus nigra/antioxidant; Morus nigra/extract/hepatoprotective.
Resumo: | In-vitro investigation of Morus nigra L. (Moraceae) has demonstrated the evidence of several antioxidant compounds. Current study was aimed to determine the phytoconstituents and hepatoprotective potential of n-hexane extract of Morus nigra. Swiss albino mice were divided into five groups: normal control, paracetamol control, silymarin control, 250 mg/kg p.o. extract for 7 days plus paracetamol 3 h later, 500 mg/kg p.o. extract for 7 days plus paracetamol 3 h later. Serum levels of liver enzymes and total bilirubin were assessed and compared between the groups by using one-way ANOVA to confirm hepatoprotective activity. HPLC analysis revealed the presence quercetin, oleanolic acid, luteolin, apigenin, vitamin C and kuwanon C. n-hexane extract of Morus nigra at dose of 250 mg/kg reduced elevated ALT by 54.3% (p&lt;0.001), AST by 55.1% (p&lt;0.01), ALP by 28.5% (p&lt;0.01) and TBR by 56.4% (p&lt;0.01) as compared to paracetamol control. The dose of 500 mg/kg of the extract reduced the ALT levels by 62.9% (p&lt;0.001), AST by 56.7% (p&lt;0.01), ALP by 33.6% (p&lt;0.01) and TBR by 54.5% (p&lt;0.01), as compared to paracetamol group. However, the reduction of liver enzymes and total bilirubin after administration of extract was comparable to the silymarin. Current study demonstrated potential hepatoprotective activity of n-hexane extract of Morus nigra.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000300631
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/s2175-97902018000318101
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.54 n.3 2018
Fonte: | info:eu-repo/semantics/openAccess