Data/hora: 08/06/2024 15:07:37

Provedor de dados: 	60	
País: 	Brazil	
Título: 	Use of Curcuma longa in cosmetics: extraction of curcuminoid pigments, development of formulations, and in vitro skin permeation studies	
Autores: 	Gonçalves,Gisele Mara Silva; Silva,Gustavo Henrique da; Barros,Pedro Paulo; Srebernich,Silvana Mariana; Shiraishi,Cecilia Toyoko Cavalcanti; Camargos,Victória Rodrigues de; Lasca,Thais Barbiero.	
Data: 	2014-12-01	
Ano: 	2014	
Palavras-chave: 	Curcuma longa/pharmacognosy; Curcumin/use/topical anti-inflammatory; Cosmetics/use of natural products; Curcuminoid pigments; Skin penetration; Natural products/use in cosmetics.	
Resumo: 	Curcuma longais a ginger family aromatic herb (Zingiberaceae) whose rhizomes contain curcuminoid pigments, including curcumin, a compound known for its anti-inflammatory effects. The objective of this study was to obtain curcuminoid-rich extracts, develop topical formulations thereof, and assess the stability and skin permeation of these formulations. Curcuma longa extracts were obtained and used to develop formulations. Skin permeation studies were conducted in a modified Franz diffusion cell system, and skin retention of curcuminoid pigments was quantified in pig ear membrane. Prepared urea-containing gel-cream formulations were unstable, whereas all others had satisfactory stability and pseudoplastic rheological behavior. The amount of curcuminoid pigments recovered from the receptor solution was negligible. The skin concentration of curcuminoid pigments retained was positive (&gt;20 µg/g of skin, mostly in the stratum corneum), considering the low skin permeability of curcumin. We conclude that development of topical formulations containing curcumin or Curcuma longaextract is feasible, as long as adjuvants are added to improve preservation and durability. The formulations developed in this study enabled penetration of curcumin limited to the superficial layers of the skin and then possibly without a risk of systemic action, thus permitting local use as a topical anti-inflammatory.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400885	
Editor: 	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas	
Relação: 	10.1590/S1984-82502014000400024	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Pharmaceutical Sciences  v.50 n.4 2014	
Fonte: 	info:eu-repo/semantics/openAccess