Data/hora: 10/06/2024 06:24:09

Provedor de dados: | Brazilian Journal of Pharmaceutical Sciences
País: | Brazil
Título: | Antineoplastic potential of the aqueous crude extract of Eugenia uniflora L. in human cervical cancer
Autores: | Núñez,Jisette González; Pinheiro,Jordânia dos Santos; Silveira,Gabriel Fernandes; Beckenkamp,Aline; Buffon,Andréia; Bruno,Alessandra Nejar.
Data: | 2018-01-01
Ano: | 2018
Palavras-chave: | Eugenia uniflora L./effects/antitumoral; Pitangueira; SiHa; HaCat; Plant extract/antitumoral; Cervical cancer.
Resumo: | Abstract Considering the high prevalence of human cervical cancer and the adverse effects of the available treatments, it is important to develop studies involving plants. Eugenia uniflora L. is a Brazilian native plant widely used in folk medicine and some biological effects have already been described. In this study, we investigated the biologicals effects of the aqueous crude extract of E. uniflora leaves in relation to the viability of human cervical cancer cells (SiHa), non-tumorigenic cells HaCaT and human lymphocytes. Our results demonstrated that different concentrations of E. uniflora’s extract significantly inhibited the viability of the Siha cell line at 24, 48 and 72 hours of treatment, but did not induce significant changes in the HaCat cell line and human lymphocytes. Tumor cells had adhesion capacity, migration processes, ability of colony forming and the potential to recover its viability after treatment. withdrawal, significantly reduced. The nuclear morphology revealed chromatin condensation, and the flow cytometry showed predominantly cell death by apoptosis in the treated tumor cells. Therefore, the E. uniflora’s extract may contribute for future studies aiming at new therapeutic perspectives for human cervical cancer.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200618
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/s2175-97902018000217267
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.54 n.2 2018
Fonte: | info:eu-repo/semantics/openAccess