Data/hora: 10/06/2024 16:57:29

Provedor de dados: 	60	
País: 	Brazil	
Título: 	Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers	
Autores: 	Fernandes,Amanda Velinna; Pydi,Chinna Raja; Verma,Ruchi; Jose,Jobin; Kumar,Lalit.	
Data: 	2020-01-01	
Ano: 	2020	
Palavras-chave: 	Fluconazole; NLCs; Nanostructured lipid carriers; Fungal infections; Full factorial design; Design of experiment.	
Resumo: 	Present study was aimed to prepare and characterize fluconazole loaded nanostructured lipid carriers (FLZ-NLCs) for the treatment of fungal infections. Fungal infections are tremendously widespread and are the often faced dermatological condition worldwide. FLZ-NLCs was prepared by ultrasonication emulsion technique using stearic acid (SA) as solid lipid, castor oil as liquid lipid and tween 20 as a surfactant. The mean diameter of optimized FLZ-NLCs were found to be 359.15 ± 9.83 nm. The drug content and entrapment efficiency of NLCs was found to be 102.97 ± 7.45% and 87 ± 0.59%, respectively. In vitro drug release studies of FLZ-NLCs showed 37.34 ± 2.08% drug release over a period of 72 h. The above studies confirmed the prepared FLZ-NLCs may be useful for the treatment of fungal infections.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100524	
Editor: 	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas	
Relação: 	10.1590/s2175-97902019000318069	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Pharmaceutical Sciences  v.56 2020	
Fonte: 	info:eu-repo/semantics/openAccess