Data/hora: 16/06/2024 03:32:23

Provedor de dados: 	60	
País: 	Brazil	
Título: 	Topical antiinflammatory activity and chemical composition of the epicuticular wax from the leaves of Eugenia beaurepaireana (Myrtaceae)	
Autores: 	Magina,Michele Debiasi Alberton; Pietrovski,Evelise Fernades; Gomig,Franciane; Falkenberg,Daniel de Barcellos; Cabrini,Daniela Almeida; Otuki,Michel Fleith; Pizzollati,Moacir Geraldo; Brighente,Inês Maria Costa.	
Data: 	2009-03-01	
Ano: 	2009	
Palavras-chave: 	Eugenia beaurepaireana/pharmacognosy; Α-amyrin; Β-amyrin; Epicuticular wax/antiinflammatory activity; Ear oedema/experimental study.	
Resumo: 	In order to verify the topical antiinflammatory effect of epicuticular wax from leaves of Eugenia beaurepaireana, it was tested in mice croton oil-induced inflammation. Our findings show that topical application of Eugenia beaurepaireana epicuticular wax was significantly active in inhibiting both oedema (Inhibitory dose 50 % (ID50) = 0.31 (0.26 - 0.39) mg.ear -1, inhibition = 79 ± 6 %) and tissue myeloperoxidase activity (indicative of polymorphonuclear leukocytes influx) (ID50 =0.34 (0.20 - 0.41) mg.ear -1, inhibition = 77 ± 4 %) in mice ear treated with croton oil. Two main compounds were detected on epicuticular wax of E. beaurepaireana. These compounds were identified as α- and β-amyrin by flame ionization detection (GC-FID) and spectroscopic methods (IR, NMR ¹H and 13C). In conclusion, the results indicate a topical antiinflammatory activity for the Eugenia specie studied and, that, at least in part, α- and β-amyrin are responsible for this activity.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000100021	
Editor: 	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas	
Relação: 	10.1590/S1984-82502009000100021	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Pharmaceutical Sciences  v.45 n.1 2009	
Fonte: 	info:eu-repo/semantics/openAccess