Data/hora: 11/06/2024 12:38:13

Provedor de dados: | 60
País: | Brazil
Título: | Preparation and characterization of liposomes loaded with silver nanoparticles obtained by green synthesis
Autores: | Espinoza,Joel Toribio; Novak,Robson Schimandeiro; Magalhães,Cássia Gonçalves; Budel,Jane Manfron; Justus,Barbara; Gonçalves,Melissa Marques; Boscardin,Patricia Mathias Döll; Farago,Paulo Vitor; Paula,Josiane de Fátima Padiha De.
Data: | 2020-01-01
Ano: | 2020
Palavras-chave: | Silver nanoparticles; Aloe vera; Sunlight; Liposomes.
Resumo: | The objective of this work was to develop and characterize liposomes loaded with silver nanoparticles (LAgNPs) to show improvement in stability characteristics. AgNPs were prepared by the green synthesis method with Aloe vera gel extract and exposure to sunlight. Liposomes were prepared by the modified reverse phase method. Particle size, polydispersity index, zeta potential, as well as the scanning electron microscopy (SEM) morphological aspects of AgNPs and LAgNPs were evaluated. In addition, was used flame atomic absorption spectroscopy to determine the amount of AgNP that was encapsulated in liposomes. The AgNPs presented as amorphous and polydisperse structures, with a mean diameter of 278.46 nm and zeta potential of -18.3 mV. LAgNPs had a mean diameter between 321 and 373 nm, the polydispersity index close to 0.2 and a zeta potential around -40 mV, which indicates greater stability to the AgNPs. The images obtained by SEM show semicircular structures for AgNPs and well-defined spherical shape for LAgNPs. The percentage of encapsulation was between 51.81 to 58.83%. These results showed that LAgNPs were obtained with adequate physicochemical characteristics as a release system.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100625
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/s2175-97902020000118601
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.56 2020
Fonte: | info:eu-repo/semantics/openAccess