Data/hora: 09/06/2024 18:07:06

Provedor de dados: | 60
País: | Brazil
Título: | A review of analytical methods for the determination of four new phosphodiesterase type 5 inhibitors in biological samples and pharmaceutical preparations
Autores: | Codevilla,Cristiane Franco; Castilhos,Tamara dos Santos; Bergold,Ana Maria.
Data: | 2013-03-01
Ano: | 2013
Palavras-chave: | Phosphodiesterase type 5 inhibitors/determination; Phosphodiesterase type 5 inhibitors/pharmaceutical preparations; Phosphodiesterase type 5 inhibitors/determination; Phosphodiesterase type 5 inhibitors/biological samples; Analytical methods; Erectile dysfunction.
Resumo: | The introduction of oral phosphodiesterase type 5 inhibitor therapy in 1998 revolutionized the treatment of erectile dysfunction. Erectile dysfunction is the most common sexual problem in men. It often has a profound effect on intimate relationships and quality of life. The analysis of pharmaceuticals is an important part of the drug development process as well as for routine analysis and quality control of commercial formulations. Whereas the determination of sildenafil citrate, vardenafil and tadalafil are well documented by a variety of methods, there are few publications about the determination of udenafil, lodenafil carbonate, mirodenafil and avanafil. The paper presents a brief review of the action mechanism, adverse effects, pharmacokinetics and the most recent analytical methods that can determine drug concentration in biological matrices and pharmaceutical formulations of these four drugs.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100002
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502013000100002
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.49 n.1 2013
Fonte: | info:eu-repo/semantics/openAccess