Data/hora: 03/06/2024 16:39:53

Provedor de dados: | 60
País: | Brazil
Título: | Development of enteric coated tablets from spray dried extract of feverfew (Tanacetum parthenium L: )
Autores: | Chaves,Juliana Siqueira; Da Costa,Fernando Batista; Freitas,Luís Alexandre Pedro de.
Data: | 2009-09-01
Ano: | 2009
Palavras-chave: | Enteric coated tablets; Flavonoids; Parthenolide; Phytomedicine; Spray-dried extract; Tanacetum parthenium.
Resumo: | Tanacetum parthenium (feverfew) is an herb that is commercialized worldwide as a therapeutic treatment for migraine. Its pharmacological effect is mainly due to the presence of the sesquiterpene lactone parthenolide as well as of flavonoids. So far, there are no studies on standardization of pre-formulations or phytomedicines containing this herb. The present study aimed at developing a pre-formulation using a standardized spray-dried extract of feverfew and further designing and standardizing enteric coated tablets. In this work, the spray-dried extract of feverfew was evaluated for its parthenolide, santin and total flavonoid content, parthenolide solubility, particle size, tapped density, hygroscopicity, angle of repose and moisture content. Tablets containing the spray-dried extract were tested for their average weight, friability, hardness, and disintegration time. The total flavonoid and parthenolide contents in the spray-dried extract were 1.31 % and 0.76% w/w, respectively. The spray-dried extract presented consistent pharmacotechnical properties and allowed its tableting by direct compression. Tablet properties were in accordance with the proposed specifications. The procedures described herein can be used to prepare and evaluate pre-formulations of feverfew with adequate properties for the development of a high-quality phytomedicine.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300024
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502009000300024
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.45 n.3 2009
Fonte: | info:eu-repo/semantics/openAccess