Data/hora: 10/06/2024 08:03:58

Provedor de dados: | Brazilian Journal of Pharmaceutical Sciences
País: | Brazil
Título: | Cytotoxic and genotoxic investigation on barbatimão [Stryphnodendron adstringens (Mart: ) Coville, 1910] extract
Autores: | Vilar,Juliana Brandstetter; D'Oliveira,Maria Inez Prudente; Santos,Suzana da Costa; Chen,Lee Chen.
Data: | 2010-12-01
Ano: | 2010
Palavras-chave: | Stryphnodendron adstringens/cytotoxicity; Stryphnodendron adstringens/genotoxicity; Barbatimão/phytochemical study.
Resumo: | Stryphnodendron adstringens (Mart.) Coville, 1910 is a small tree, distributed widely throughout the Cerrado region of Brazil and named "barbatimão" by the Tupi-Guarani tribes, which presents astringent properties. Its ethnopharmacological uses comprise, among others, anti-inflammatory and wound healing action, and it is used in the treatment of diarrhea and gynecological problems. The phytotherapeutic use of 'barbatimão' is largely related to its tannin content, which is abundant in its bark. The main goal of the present study was to evaluate the cytotoxic, mutagenic, and genotoxic potential of the lyophilized solution of the stem bark of S. adstringens, using the Ames test, the SOS-Inductest and the SOS-Chromotest. S. adstringens presented cytotoxic activity in all tested systems, did not present mutagenic activity detectable by the Ames test and SOS-Chromotest, and showed some genotoxic effect on the SOS-Inductest. However, the metabolization of the extract by S9 fraction attenuated its genotoxic and cytotoxic activities.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400010
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502010000400010
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.46 n.4 2010
Fonte: | info:eu-repo/semantics/openAccess